-
Cholesterol Metabolism, LDL, HDL and other Lipoproteins, Animation
(USMLE topics) The science behind the GOOD and BAD cholesterol. Cholesterol transport and pathways, drugs used for treatment of atherosclerosis.
This video is available for instant download licensing here: https://www.alilamedicalmedia.com/-/galleries/narrated-videos-by-topics/hypertensioncholesterol/-/medias/47f9fe8c-8be2-4c09-a87b-a2cddc501d29-cholesterol-metabolism-narrated-animation
Purchase PDF (video text + images) here: https://www.alilamedicalmedia.com/-/galleries/pdf-video-scripts-with-images/digestive-system-pdfs/-/medias/81ebdade-5fcf-4226-aac3-bd7a5f1bd3f6-cholesterol-metabolism-3-pages-3-images
©Alila Medical Media. All rights reserved.
Voice by Vicky Prizmic
Support us on Patreon and get FREE downloads and other great rewards: patreon.com/AlilaMedicalMedia
All images/v...
published: 01 May 2018
-
HDL ( Reverse cholesterol transport)
HDL stands for high-density lipoproteins. It is sometimes called the "good" cholesterol because it carries cholesterol from other parts of your body back to your liver. Your liver then removes the cholesterol from your body. LDL stands for low-density lipoproteins
published: 26 Jul 2020
-
HDL vs LDL: Cholesterol Ratio
It’s a bit of misconception the idea about HDL is being the good cholesterol and LDL being the bad cholesterol, says Lisa Klein-Davis, Physician Assistant with Miami Cardiac & Vascular Institute.
She explains some people can have the same amount of what is bad or good cholesterol, but some people might be more prone to particles being atherogenic or plaque forming type particles where somebody else with the same number.
Dr. Jonathan Fialkow, Chief Population Health Officer with Baptist Health South Florida, agrees with her and affirms he tells people there’s no such thing as good and bad cholesterol. “There’s cholesterol,” he affirms.
He also says cholesterol doesn’t travel freely in the body, it’s encased in lipoprotein particles and there is not a cholesterol disease. The disease is a...
published: 04 Dec 2018
-
The 5 Types of HDL and How to Improve Your Levels with Nutrition
Click Here to Subscribe: http://Bit.ly/ThomasVid
Get MY Recommendation on Groceries Delivered to Your Doorstep with Thrive Market: http://ThriveMarket.com/Thomas
This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. The best way that you can directly support my channel, is by supporting the brands that help make this all possible. Any product that you see on my channel is a product that I also use personally, regardless of any paid promotion.
Get my Free Newsletter and Downloadable Cheatsheets (eating out, travel, etc): https://www.thomasdelauer.com/life-optimization-tactics/
Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer...
published: 02 Jun 2020
-
Metabolism | Lipoprotein Metabolism | Chylomicrons, VLDL, IDL, LDL, & HDL
Official Ninja Nerd Website: https://ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be discussing the metabolism of lipoproteins- Lipoprotein Metabolism. During this lecture we talk specifically about chylomicrons in the exogenous pathway. We also talk about VLDL, IDL and LDL and their role in the endogenous pathway. Lastly, we discuss HDL and it's role in reverse cholesterol transport as well as normal serum cholesterol levels. We hope you enjoy this lecture and be sure to support us below!
Join this channel to get access to perks:
https://www.youtube.com/channel/UC6QYFutt9cluQ3uSM963_KQ/join
APPAREL |
We are switching merchandise suppliers.
DONATE
PATREON | https://www.patreon.com/NinjaNerdScience
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SOCIA...
published: 06 Jan 2018
-
Good & Bad #Cholesterol: (#HDL and #LDL)
In this 3D medical animation video, we have explained the mechanism of good and bad cholesterol in body.
Learn More: https://ecgkid.com
_____________________________________________________________________
Cholesterol is carried through the bloodstream by proteins known as "lipoproteins." Lipoproteins are two types of proteins that transport cholesterol throughout the body:
The majority of your body's cholesterol is LDL (low-density lipoprotein), also known as "bad" cholesterol. High LDL cholesterol levels increase your risk of heart disease and stroke.
The "good" cholesterol, HDL (high-density lipoprotein), absorbs cholesterol and transports it back to the liver. It is then flushed from the body by the liver. High HDL cholesterol levels can reduce your risk of heart disease and stroke.
published: 24 Apr 2022
-
Atherosclerosis | Cholesterol, LDL, HDL, Triglycerides
Atherosclerosis & Cholesterol. Are LDL, HDL and triglycerides good measures of atherosclerosis risk? A look at atherosclerosis, cholesterol and tips to dodge a heart attack.
how to dodge a heart attack? let's look at atherosclerosis aka plaque and best lab tests to prevent it
LDL? LDL-cholesterol? people call them both LDL. HDL? VLDL? IDL…
cholesterol is carried in our bloodstream by lipoproteins. lipoproteins are the buses and cholesterol is the passenger
some get stuck in the artery wall. if there’s a lot of lipoproteins in the blood, over the years this forms plaque aka atherosclerosis
plaque can block blood flow and cause angina (chest pain when the heart muscle doesnt get enough blood). plaque can also break and clot causing a heart attack
lipoproteins: LDL (low dens lipoprotein...
published: 22 Mar 2021
-
Lipids Series-HDL Can It Be Too High? Is Treatment Available?
Mayo Clinic Division of Preventive Cardiology will be preparing a series of recordings focusing on Cardiovascular Disease states. This is the Lipids Series and this particular one focuses on HDL and Treatments
published: 04 Jan 2021
-
प्राकृतिक रूपमा एचडीएल ( HDL ) कसरी बढाउने? | Raise your HDL in few steps
You can raise your HDL cholesterol (good cholesterol) with these 5 easy steps. These steps are reliable, easy and the results are permanent as long as you keep doing the steps. A high HDL is very healthy and prevents heart attack and stroke in people just like you.
Don't worry about lowering your LDL, focus all your effort on raising your HDL because it will protect you. There is no prescription drug that will raise your HDL safely and reliably, and very few supplements that actually work.
** QUITTING SMOKING WILL ALSO RAISE YOUR HDL-C! **
Good Berberine: https://amzn.to/3e1ccOj
LIES MY DOCTOR TOLD ME: https://amzn.to/2MtuDjo
REAL SALT you Need: http://bit.ly/RealSalts
-- Research --
Low-Carb Diet
https://pubmed.ncbi.nlm.nih.gov/26224...
https://pubmed.ncbi.nlm.nih.gov/24075...
ht...
published: 06 Mar 2024
-
240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.
Watch the full episode and view show notes here: http://bit.ly/3XZt1gC
Become a member to receive exclusive content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Dan Rader is a Professor at the Perelman School of Medicine at the University of Pennsylvania, where he conducts translational research on lipoprotein metabolism and atherosclerosis with a particular focus on the function of high-density lipoproteins (HDLs). In this episode, Dan goes in-depth on HDL biology, including the genesis of HDL, its metabolism, function, and how this relates to atherosclerotic cardiovascular disease (ASCVD). He explains why having high HDL-C levels does not directly translate to a low risk of cardiovascular disease and reveals resea...
published: 30 Jan 2023
3:46
Cholesterol Metabolism, LDL, HDL and other Lipoproteins, Animation
(USMLE topics) The science behind the GOOD and BAD cholesterol. Cholesterol transport and pathways, drugs used for treatment of atherosclerosis.
This video i...
(USMLE topics) The science behind the GOOD and BAD cholesterol. Cholesterol transport and pathways, drugs used for treatment of atherosclerosis.
This video is available for instant download licensing here: https://www.alilamedicalmedia.com/-/galleries/narrated-videos-by-topics/hypertensioncholesterol/-/medias/47f9fe8c-8be2-4c09-a87b-a2cddc501d29-cholesterol-metabolism-narrated-animation
Purchase PDF (video text + images) here: https://www.alilamedicalmedia.com/-/galleries/pdf-video-scripts-with-images/digestive-system-pdfs/-/medias/81ebdade-5fcf-4226-aac3-bd7a5f1bd3f6-cholesterol-metabolism-3-pages-3-images
©Alila Medical Media. All rights reserved.
Voice by Vicky Prizmic
Support us on Patreon and get FREE downloads and other great rewards: patreon.com/AlilaMedicalMedia
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Despite having a BAD reputation as a high-risk factor for cardiovascular diseases, cholesterol is an ESSENTIAL component of all animal cells. It is an INTEGRAL part of the cell membrane, providing membrane FLUIDITY and participating in a number of cellular processes. Cholesterol also serves as a PRECURSOR for production of bile, steroid hormones, and vitamin D. While the body can obtain cholesterol from food, many cells SYNTHESIZE their own ENDOGENOUS cholesterol. Cellular production of cholesterol is under NEGATIVE FEEDBACK control. LOW levels of intracellular cholesterol INDUCE its own production, while HIGH cholesterol levels INHIBIT it.
Cholesterol, together with other lipids, is transported in blood plasma within large particles known as LIPOPROTEINS. A lipoprotein is an assembly of lipids and proteins. Lipoproteins are classified based on their DENSITY. Because lipids are LIGHTER than proteins, particles that contain MORE lipids are LARGER in size but have LOWER density. Different types of lipoproteins have different sets of proteins on their surface. These proteins serve as “ADDRESS tags”, determining the DESTINATION, and hence FUNCTION, of each lipoprotein. For example, LOW-density lipoprotein, LDL, carries cholesterol FROM the liver to other tissues, while HIGH-density lipoprotein, HDL, RETURNS excess cholesterol TO the liver.
Major events in cholesterol metabolism include:
- Dietary cholesterol ABSORBED in the intestine and carried in chylomicron to the liver.
- The liver PACKAGES its cholesterol pool - a combination of endogenous and dietary - together with triglycerides, another type of lipid, into particles of VERY-LOW-density lipoprotein, VLDL.
- VLDL travels in bloodstream to other organs. During circulation, muscle and adipose tissues EXTRACT triglycerides from VLDL, turning it into LOW-density lipoprotein, LDL.
- Peripheral cells TAKE UP LDL by endocytosis, using LDL receptor. Cholesterol is used in cell membrane and other functions.
- EXCESS cholesterol is exported from the cells and delivered to HIGH-density lipoprotein, HDL, to be RETURNED to the liver in a process called REVERSE cholesterol transport.
- The liver uses cholesterol to produce BILE; bile is secreted to the intestine, where it helps break down fats. Part of this bile is EXCRETED in feces; the rest is RECYCLED back to the liver.
LDL has the highest cholesterol content and is the MAJOR carrier of cholesterol in the blood. High levels of LDL in the blood are associated with cholesterol plaque build-up and cardiovascular diseases such as heart attacks and strokes. For this reason, LDL is known as “BAD” cholesterol. On the other hand, HDL is called “GOOD” cholesterol, because it REMOVES EXCESS cholesterol from tissues and bloodstream.
Common drugs used to LOWER cholesterol include: INHIBITORS of endogenous cholesterol PRODUCTION; INHIBITORS of intestinal cholesterol ABSORPTION; and INHIBITORS of bile reuptake.
https://wn.com/Cholesterol_Metabolism,_Ldl,_Hdl_And_Other_Lipoproteins,_Animation
(USMLE topics) The science behind the GOOD and BAD cholesterol. Cholesterol transport and pathways, drugs used for treatment of atherosclerosis.
This video is available for instant download licensing here: https://www.alilamedicalmedia.com/-/galleries/narrated-videos-by-topics/hypertensioncholesterol/-/medias/47f9fe8c-8be2-4c09-a87b-a2cddc501d29-cholesterol-metabolism-narrated-animation
Purchase PDF (video text + images) here: https://www.alilamedicalmedia.com/-/galleries/pdf-video-scripts-with-images/digestive-system-pdfs/-/medias/81ebdade-5fcf-4226-aac3-bd7a5f1bd3f6-cholesterol-metabolism-3-pages-3-images
©Alila Medical Media. All rights reserved.
Voice by Vicky Prizmic
Support us on Patreon and get FREE downloads and other great rewards: patreon.com/AlilaMedicalMedia
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Despite having a BAD reputation as a high-risk factor for cardiovascular diseases, cholesterol is an ESSENTIAL component of all animal cells. It is an INTEGRAL part of the cell membrane, providing membrane FLUIDITY and participating in a number of cellular processes. Cholesterol also serves as a PRECURSOR for production of bile, steroid hormones, and vitamin D. While the body can obtain cholesterol from food, many cells SYNTHESIZE their own ENDOGENOUS cholesterol. Cellular production of cholesterol is under NEGATIVE FEEDBACK control. LOW levels of intracellular cholesterol INDUCE its own production, while HIGH cholesterol levels INHIBIT it.
Cholesterol, together with other lipids, is transported in blood plasma within large particles known as LIPOPROTEINS. A lipoprotein is an assembly of lipids and proteins. Lipoproteins are classified based on their DENSITY. Because lipids are LIGHTER than proteins, particles that contain MORE lipids are LARGER in size but have LOWER density. Different types of lipoproteins have different sets of proteins on their surface. These proteins serve as “ADDRESS tags”, determining the DESTINATION, and hence FUNCTION, of each lipoprotein. For example, LOW-density lipoprotein, LDL, carries cholesterol FROM the liver to other tissues, while HIGH-density lipoprotein, HDL, RETURNS excess cholesterol TO the liver.
Major events in cholesterol metabolism include:
- Dietary cholesterol ABSORBED in the intestine and carried in chylomicron to the liver.
- The liver PACKAGES its cholesterol pool - a combination of endogenous and dietary - together with triglycerides, another type of lipid, into particles of VERY-LOW-density lipoprotein, VLDL.
- VLDL travels in bloodstream to other organs. During circulation, muscle and adipose tissues EXTRACT triglycerides from VLDL, turning it into LOW-density lipoprotein, LDL.
- Peripheral cells TAKE UP LDL by endocytosis, using LDL receptor. Cholesterol is used in cell membrane and other functions.
- EXCESS cholesterol is exported from the cells and delivered to HIGH-density lipoprotein, HDL, to be RETURNED to the liver in a process called REVERSE cholesterol transport.
- The liver uses cholesterol to produce BILE; bile is secreted to the intestine, where it helps break down fats. Part of this bile is EXCRETED in feces; the rest is RECYCLED back to the liver.
LDL has the highest cholesterol content and is the MAJOR carrier of cholesterol in the blood. High levels of LDL in the blood are associated with cholesterol plaque build-up and cardiovascular diseases such as heart attacks and strokes. For this reason, LDL is known as “BAD” cholesterol. On the other hand, HDL is called “GOOD” cholesterol, because it REMOVES EXCESS cholesterol from tissues and bloodstream.
Common drugs used to LOWER cholesterol include: INHIBITORS of endogenous cholesterol PRODUCTION; INHIBITORS of intestinal cholesterol ABSORPTION; and INHIBITORS of bile reuptake.
- published: 01 May 2018
- views: 1110460
6:40
HDL ( Reverse cholesterol transport)
HDL stands for high-density lipoproteins. It is sometimes called the "good" cholesterol because it carries cholesterol from other parts of your body back to you...
HDL stands for high-density lipoproteins. It is sometimes called the "good" cholesterol because it carries cholesterol from other parts of your body back to your liver. Your liver then removes the cholesterol from your body. LDL stands for low-density lipoproteins
https://wn.com/Hdl_(_Reverse_Cholesterol_Transport)
HDL stands for high-density lipoproteins. It is sometimes called the "good" cholesterol because it carries cholesterol from other parts of your body back to your liver. Your liver then removes the cholesterol from your body. LDL stands for low-density lipoproteins
- published: 26 Jul 2020
- views: 97417
2:09
HDL vs LDL: Cholesterol Ratio
It’s a bit of misconception the idea about HDL is being the good cholesterol and LDL being the bad cholesterol, says Lisa Klein-Davis, Physician Assistant with ...
It’s a bit of misconception the idea about HDL is being the good cholesterol and LDL being the bad cholesterol, says Lisa Klein-Davis, Physician Assistant with Miami Cardiac & Vascular Institute.
She explains some people can have the same amount of what is bad or good cholesterol, but some people might be more prone to particles being atherogenic or plaque forming type particles where somebody else with the same number.
Dr. Jonathan Fialkow, Chief Population Health Officer with Baptist Health South Florida, agrees with her and affirms he tells people there’s no such thing as good and bad cholesterol. “There’s cholesterol,” he affirms.
He also says cholesterol doesn’t travel freely in the body, it’s encased in lipoprotein particles and there is not a cholesterol disease. The disease is atherosclerosis.
https://wn.com/Hdl_Vs_Ldl_Cholesterol_Ratio
It’s a bit of misconception the idea about HDL is being the good cholesterol and LDL being the bad cholesterol, says Lisa Klein-Davis, Physician Assistant with Miami Cardiac & Vascular Institute.
She explains some people can have the same amount of what is bad or good cholesterol, but some people might be more prone to particles being atherogenic or plaque forming type particles where somebody else with the same number.
Dr. Jonathan Fialkow, Chief Population Health Officer with Baptist Health South Florida, agrees with her and affirms he tells people there’s no such thing as good and bad cholesterol. “There’s cholesterol,” he affirms.
He also says cholesterol doesn’t travel freely in the body, it’s encased in lipoprotein particles and there is not a cholesterol disease. The disease is atherosclerosis.
- published: 04 Dec 2018
- views: 22748
8:44
The 5 Types of HDL and How to Improve Your Levels with Nutrition
Click Here to Subscribe: http://Bit.ly/ThomasVid
Get MY Recommendation on Groceries Delivered to Your Doorstep with Thrive Market: http://ThriveMarket.com/Thoma...
Click Here to Subscribe: http://Bit.ly/ThomasVid
Get MY Recommendation on Groceries Delivered to Your Doorstep with Thrive Market: http://ThriveMarket.com/Thomas
This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. The best way that you can directly support my channel, is by supporting the brands that help make this all possible. Any product that you see on my channel is a product that I also use personally, regardless of any paid promotion.
Get my Free Newsletter and Downloadable Cheatsheets (eating out, travel, etc): https://www.thomasdelauer.com/life-optimization-tactics/
Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer
Special Thanks to my team and Nicholas Norwitz - Oxford PhD Researcher and Harvard Med Student - for working diligently on research as well!
It's important that I am honest and to say that this video does have a sponsorship from Thrive Market, supporting them is a good way to support my channel!
The 5 Types of HDL and How to Improve with Nutrition- Thomas DeLauer
Imagine you had a family of six, a mom a and five sons. The mom, being rather uncreative, named her first four sons Henry, Henry, Henry, and Henry. When she had her fifth child, a friend nicely suggested to her that she name it something original. What a thought!? She named her last son Lewis. Now, if you were told the children in this family were named Henry and Lewis, you’d be forgiven for assuming that there were only two children. And yet, there are five, each with distinct personalities.
This video is mostly about the children named Henry. We will talk about Lewis a bit at the end. All the Henry’s are very well behaved. You could call them all “good” boys. And, you guessed it, in our analogy, the Henry’s are High Density Lipoprotein (HDL), which if often called “good” cholesterol. The mother is the liver, which creates several different HDL cholesterol particles (maybe not exactly four… hard to say) and one type of LDL cholesterol particle (Lewis; hold tight on Lewis).
It’s true, HDL is great! Still, each HDL, each Henry, is unique, and great in different ways. Here are some of the things that HDLs do that are good for the body:
HDL engages in “reverse cholesterol transport/cholesterol efflux” – this means removing cholesterol from arteries and plaques; this is the beneficial function most doctors think about when they hear “HDL.”
HDL is also an antioxidant; it reduces oxidized lipoproteins and oxidized LDL.
HDL is also anti-inflammatory and modulates inflammatory factors.
HDL also modulates platelet activity.
HDL also modulates insulin secretion.
But which Henry does which just best? Well, scientists are still trying to figure that one out! The HDLs (Henry’s) are secreted in several different forms from the liver, and each form probably correlates with optimization for a particular set of healthful functions.
Right now, there are many different ways of subclassifying HDL types. You can classify based on density (HDL2 is buoyant and HDL3 is dense). You can classify based on size (small, medium, and large diameters; most common and more below). You can classify based on mass/charge ratio, and so on. When to use different techniques – ultracentrifugation, nuclear magnetic resonance, ion gel electrophoresis, etc. – to categorize HDLs is confusing and we won’t go down that rabbit hole.
Now, what about Lewis. Lewis is a good kid, but unlike his brothers, was susceptible to the “terrible 2s,” i.e. when he was small, he was a giant pain in the butt. Bigger, older Lewis is good, but little (and medium) Lewis was a horror. Similarly, your liver secretes one type of LDL particle that is good when it’s big, but bad when it’s small. I’ve done other videos on LDL (links 4-5) so you can check those out in the links below.
Links
https://ezproxy-prd.bodleian.ox.ac.uk:2056/science/article/pii/S1043276014000873?via%3Dihub
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971193/pdf/nihms808635.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593254/pdf/fphar-06-00218.pdf
Foods to Increase HDL
Olive Oil: https://www.ncbi.nlm.nih.gov/pubmed/23051557
Mediterranean: https://www.ahajournals.org/doi/full/10.1161/circulationaha.116.023712
https://www.mdpi.com/2072-6643/8/1/15
Avocado: https://www.ahajournals.org/doi/10.1161/JAHA.114.001355
Coffee: https://www.ncbi.nlm.nih.gov/pubmed/20075335
Fatty Fish: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691715/pdf/nutrients-09-01099.pdf
Nicholas Norwitz - Oxford PhD Researcher and Harvard Med Student:
https://www.dpag.ox.ac.uk/team/nicholas-norwitz
https://wn.com/The_5_Types_Of_Hdl_And_How_To_Improve_Your_Levels_With_Nutrition
Click Here to Subscribe: http://Bit.ly/ThomasVid
Get MY Recommendation on Groceries Delivered to Your Doorstep with Thrive Market: http://ThriveMarket.com/Thomas
This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. The best way that you can directly support my channel, is by supporting the brands that help make this all possible. Any product that you see on my channel is a product that I also use personally, regardless of any paid promotion.
Get my Free Newsletter and Downloadable Cheatsheets (eating out, travel, etc): https://www.thomasdelauer.com/life-optimization-tactics/
Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer
Special Thanks to my team and Nicholas Norwitz - Oxford PhD Researcher and Harvard Med Student - for working diligently on research as well!
It's important that I am honest and to say that this video does have a sponsorship from Thrive Market, supporting them is a good way to support my channel!
The 5 Types of HDL and How to Improve with Nutrition- Thomas DeLauer
Imagine you had a family of six, a mom a and five sons. The mom, being rather uncreative, named her first four sons Henry, Henry, Henry, and Henry. When she had her fifth child, a friend nicely suggested to her that she name it something original. What a thought!? She named her last son Lewis. Now, if you were told the children in this family were named Henry and Lewis, you’d be forgiven for assuming that there were only two children. And yet, there are five, each with distinct personalities.
This video is mostly about the children named Henry. We will talk about Lewis a bit at the end. All the Henry’s are very well behaved. You could call them all “good” boys. And, you guessed it, in our analogy, the Henry’s are High Density Lipoprotein (HDL), which if often called “good” cholesterol. The mother is the liver, which creates several different HDL cholesterol particles (maybe not exactly four… hard to say) and one type of LDL cholesterol particle (Lewis; hold tight on Lewis).
It’s true, HDL is great! Still, each HDL, each Henry, is unique, and great in different ways. Here are some of the things that HDLs do that are good for the body:
HDL engages in “reverse cholesterol transport/cholesterol efflux” – this means removing cholesterol from arteries and plaques; this is the beneficial function most doctors think about when they hear “HDL.”
HDL is also an antioxidant; it reduces oxidized lipoproteins and oxidized LDL.
HDL is also anti-inflammatory and modulates inflammatory factors.
HDL also modulates platelet activity.
HDL also modulates insulin secretion.
But which Henry does which just best? Well, scientists are still trying to figure that one out! The HDLs (Henry’s) are secreted in several different forms from the liver, and each form probably correlates with optimization for a particular set of healthful functions.
Right now, there are many different ways of subclassifying HDL types. You can classify based on density (HDL2 is buoyant and HDL3 is dense). You can classify based on size (small, medium, and large diameters; most common and more below). You can classify based on mass/charge ratio, and so on. When to use different techniques – ultracentrifugation, nuclear magnetic resonance, ion gel electrophoresis, etc. – to categorize HDLs is confusing and we won’t go down that rabbit hole.
Now, what about Lewis. Lewis is a good kid, but unlike his brothers, was susceptible to the “terrible 2s,” i.e. when he was small, he was a giant pain in the butt. Bigger, older Lewis is good, but little (and medium) Lewis was a horror. Similarly, your liver secretes one type of LDL particle that is good when it’s big, but bad when it’s small. I’ve done other videos on LDL (links 4-5) so you can check those out in the links below.
Links
https://ezproxy-prd.bodleian.ox.ac.uk:2056/science/article/pii/S1043276014000873?via%3Dihub
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971193/pdf/nihms808635.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593254/pdf/fphar-06-00218.pdf
Foods to Increase HDL
Olive Oil: https://www.ncbi.nlm.nih.gov/pubmed/23051557
Mediterranean: https://www.ahajournals.org/doi/full/10.1161/circulationaha.116.023712
https://www.mdpi.com/2072-6643/8/1/15
Avocado: https://www.ahajournals.org/doi/10.1161/JAHA.114.001355
Coffee: https://www.ncbi.nlm.nih.gov/pubmed/20075335
Fatty Fish: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691715/pdf/nutrients-09-01099.pdf
Nicholas Norwitz - Oxford PhD Researcher and Harvard Med Student:
https://www.dpag.ox.ac.uk/team/nicholas-norwitz
- published: 02 Jun 2020
- views: 64788
1:03:35
Metabolism | Lipoprotein Metabolism | Chylomicrons, VLDL, IDL, LDL, & HDL
Official Ninja Nerd Website: https://ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be discussing the metabolism of lipoproteins- Lipopr...
Official Ninja Nerd Website: https://ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be discussing the metabolism of lipoproteins- Lipoprotein Metabolism. During this lecture we talk specifically about chylomicrons in the exogenous pathway. We also talk about VLDL, IDL and LDL and their role in the endogenous pathway. Lastly, we discuss HDL and it's role in reverse cholesterol transport as well as normal serum cholesterol levels. We hope you enjoy this lecture and be sure to support us below!
Join this channel to get access to perks:
https://www.youtube.com/channel/UC6QYFutt9cluQ3uSM963_KQ/join
APPAREL |
We are switching merchandise suppliers.
DONATE
PATREON | https://www.patreon.com/NinjaNerdScience
PAYPAL | https://www.paypal.com/paypalme/ninjanerdscience
SOCIAL MEDIA
FACEBOOK | https://www.facebook.com/NinjaNerdlectures
INSTAGRAM | https://www.instagram.com/ninjanerdlectures
TWITTER | https://twitter.com/ninjanerdsci
@NinjaNerdSci
DISCORD | https://discord.gg/3srTG4dngW
#ninjanerd #LipoproteinMetabolism #Metabolism
https://wn.com/Metabolism_|_Lipoprotein_Metabolism_|_Chylomicrons,_Vldl,_Idl,_Ldl,_Hdl
Official Ninja Nerd Website: https://ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be discussing the metabolism of lipoproteins- Lipoprotein Metabolism. During this lecture we talk specifically about chylomicrons in the exogenous pathway. We also talk about VLDL, IDL and LDL and their role in the endogenous pathway. Lastly, we discuss HDL and it's role in reverse cholesterol transport as well as normal serum cholesterol levels. We hope you enjoy this lecture and be sure to support us below!
Join this channel to get access to perks:
https://www.youtube.com/channel/UC6QYFutt9cluQ3uSM963_KQ/join
APPAREL |
We are switching merchandise suppliers.
DONATE
PATREON | https://www.patreon.com/NinjaNerdScience
PAYPAL | https://www.paypal.com/paypalme/ninjanerdscience
SOCIAL MEDIA
FACEBOOK | https://www.facebook.com/NinjaNerdlectures
INSTAGRAM | https://www.instagram.com/ninjanerdlectures
TWITTER | https://twitter.com/ninjanerdsci
@NinjaNerdSci
DISCORD | https://discord.gg/3srTG4dngW
#ninjanerd #LipoproteinMetabolism #Metabolism
- published: 06 Jan 2018
- views: 1087565
1:33
Good & Bad #Cholesterol: (#HDL and #LDL)
In this 3D medical animation video, we have explained the mechanism of good and bad cholesterol in body.
Learn More: https://ecgkid.com
________________________...
In this 3D medical animation video, we have explained the mechanism of good and bad cholesterol in body.
Learn More: https://ecgkid.com
_____________________________________________________________________
Cholesterol is carried through the bloodstream by proteins known as "lipoproteins." Lipoproteins are two types of proteins that transport cholesterol throughout the body:
The majority of your body's cholesterol is LDL (low-density lipoprotein), also known as "bad" cholesterol. High LDL cholesterol levels increase your risk of heart disease and stroke.
The "good" cholesterol, HDL (high-density lipoprotein), absorbs cholesterol and transports it back to the liver. It is then flushed from the body by the liver. High HDL cholesterol levels can reduce your risk of heart disease and stroke.
https://wn.com/Good_Bad_Cholesterol_(_Hdl_And_Ldl)
In this 3D medical animation video, we have explained the mechanism of good and bad cholesterol in body.
Learn More: https://ecgkid.com
_____________________________________________________________________
Cholesterol is carried through the bloodstream by proteins known as "lipoproteins." Lipoproteins are two types of proteins that transport cholesterol throughout the body:
The majority of your body's cholesterol is LDL (low-density lipoprotein), also known as "bad" cholesterol. High LDL cholesterol levels increase your risk of heart disease and stroke.
The "good" cholesterol, HDL (high-density lipoprotein), absorbs cholesterol and transports it back to the liver. It is then flushed from the body by the liver. High HDL cholesterol levels can reduce your risk of heart disease and stroke.
- published: 24 Apr 2022
- views: 900
7:52
Atherosclerosis | Cholesterol, LDL, HDL, Triglycerides
Atherosclerosis & Cholesterol. Are LDL, HDL and triglycerides good measures of atherosclerosis risk? A look at atherosclerosis, cholesterol and tips to dodge a ...
Atherosclerosis & Cholesterol. Are LDL, HDL and triglycerides good measures of atherosclerosis risk? A look at atherosclerosis, cholesterol and tips to dodge a heart attack.
how to dodge a heart attack? let's look at atherosclerosis aka plaque and best lab tests to prevent it
LDL? LDL-cholesterol? people call them both LDL. HDL? VLDL? IDL…
cholesterol is carried in our bloodstream by lipoproteins. lipoproteins are the buses and cholesterol is the passenger
some get stuck in the artery wall. if there’s a lot of lipoproteins in the blood, over the years this forms plaque aka atherosclerosis
plaque can block blood flow and cause angina (chest pain when the heart muscle doesnt get enough blood). plaque can also break and clot causing a heart attack
lipoproteins: LDL (low dens lipoprotein). VLDL or very low density lipoprotein
LDL and VLDL are the same family. there’s other families of lipoproteins but these are the main ones that cause atherosclerosis
this family of lipoproteins includes LDLs, VLDLs etc. they all carry apoB.
we can measure these lipoproteins by measuring apoB
lipoproteins cause atherosclerosis but blood work measures LDL-cholesterol (cholesterol in LDL) and triglycerides. they estimate risk of atherosclerosis
European atherosclerosis society: LDL-cholesterol is a satisfactory surrogate for LDL particle number. so high LDL-cholesterol is a red flag. and same for triglycerides
online: focus on LDL-cholesterol, ignoring triglycerides vs focus on triglycerides & ignoring LDL-cholesterol
both markers of lipoproteins that cause atherosclerosis. risk of atherosclerosis determined by apoB particles regardless of lipids… benefit of lipid-lowering (so, lowering cholesterol or triglycerides) proportional to reduction in apoB regardless of the change in LDL-Cholesterol or triglycerides
if LDL-cholesterol is high, number of LDL lipoproteins is often high. high LDL-cholesterol is a red flag and indicates high apoB
cholesterol/triglycerides reflect lipoproteins. exceptions: lipoproteins rule, not LDL-cholesterol or triglycerides
normal number of lipoproteins, normal apoB + high LDL-cholesterol/triglycerides=normal risk
high lipoproteins, high apoB + normal cholesterol/triglycerides= high risk of atherosclerosis
LDL-c/triglycerides are like the check engine light. checking engine directly = apoB
HDL-cholesterol aka ‘good cholesterol’?
people with high HDL-cholesterol tend to have less heart disease
causal relationship? raise HDL-cholesterol specifically
analysis: raising HDL-cholesterol did not lower atherosclerosis risk. raising HDL-cholesterol offers no CV protection
“the effects on cardiovascular disease of foods or nutrients cannot be judged from changes in HDL cholesterol”
HDL-cholesterol: correlates. doesn’t cause benefit. same for ratios using hdl-cholesterol
raising my HDL-cholesterol does nothing for risk
high HDL-cholesterol = distraction
key concepts to dodge atherosclerosis and a heart attack:
1) high apoB buses, apoB lipoprots = risk of atherosclerosis
2) We can measure apo B lipoproteins by measuring apoB
3) LDL-cholesterol and triglycerides are useful but not perfect
4) careful with HDL-cholest
improving our lipids including apoB: diet. more detail on lipids in your blood work
Connect with me:
Facebook: https://www.facebook.com/DrGilCarvalho/
Twitter: https://twitter.com/NutritionMadeS3
Animations: Even Topland @toplandmedia
References:
https://academic.oup.com/eurheartj/article/38/32/2459/3745109
https://jamanetwork.com/journals/jama/article-abstract/2768850
https://jamanetwork.com/journals/jamacardiology/article-abstract/2753612
HDL-cholesterol:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103514/
https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.119.044687
Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.
#NutritionMadeSimple #GilCarvalho
https://wn.com/Atherosclerosis_|_Cholesterol,_Ldl,_Hdl,_Triglycerides
Atherosclerosis & Cholesterol. Are LDL, HDL and triglycerides good measures of atherosclerosis risk? A look at atherosclerosis, cholesterol and tips to dodge a heart attack.
how to dodge a heart attack? let's look at atherosclerosis aka plaque and best lab tests to prevent it
LDL? LDL-cholesterol? people call them both LDL. HDL? VLDL? IDL…
cholesterol is carried in our bloodstream by lipoproteins. lipoproteins are the buses and cholesterol is the passenger
some get stuck in the artery wall. if there’s a lot of lipoproteins in the blood, over the years this forms plaque aka atherosclerosis
plaque can block blood flow and cause angina (chest pain when the heart muscle doesnt get enough blood). plaque can also break and clot causing a heart attack
lipoproteins: LDL (low dens lipoprotein). VLDL or very low density lipoprotein
LDL and VLDL are the same family. there’s other families of lipoproteins but these are the main ones that cause atherosclerosis
this family of lipoproteins includes LDLs, VLDLs etc. they all carry apoB.
we can measure these lipoproteins by measuring apoB
lipoproteins cause atherosclerosis but blood work measures LDL-cholesterol (cholesterol in LDL) and triglycerides. they estimate risk of atherosclerosis
European atherosclerosis society: LDL-cholesterol is a satisfactory surrogate for LDL particle number. so high LDL-cholesterol is a red flag. and same for triglycerides
online: focus on LDL-cholesterol, ignoring triglycerides vs focus on triglycerides & ignoring LDL-cholesterol
both markers of lipoproteins that cause atherosclerosis. risk of atherosclerosis determined by apoB particles regardless of lipids… benefit of lipid-lowering (so, lowering cholesterol or triglycerides) proportional to reduction in apoB regardless of the change in LDL-Cholesterol or triglycerides
if LDL-cholesterol is high, number of LDL lipoproteins is often high. high LDL-cholesterol is a red flag and indicates high apoB
cholesterol/triglycerides reflect lipoproteins. exceptions: lipoproteins rule, not LDL-cholesterol or triglycerides
normal number of lipoproteins, normal apoB + high LDL-cholesterol/triglycerides=normal risk
high lipoproteins, high apoB + normal cholesterol/triglycerides= high risk of atherosclerosis
LDL-c/triglycerides are like the check engine light. checking engine directly = apoB
HDL-cholesterol aka ‘good cholesterol’?
people with high HDL-cholesterol tend to have less heart disease
causal relationship? raise HDL-cholesterol specifically
analysis: raising HDL-cholesterol did not lower atherosclerosis risk. raising HDL-cholesterol offers no CV protection
“the effects on cardiovascular disease of foods or nutrients cannot be judged from changes in HDL cholesterol”
HDL-cholesterol: correlates. doesn’t cause benefit. same for ratios using hdl-cholesterol
raising my HDL-cholesterol does nothing for risk
high HDL-cholesterol = distraction
key concepts to dodge atherosclerosis and a heart attack:
1) high apoB buses, apoB lipoprots = risk of atherosclerosis
2) We can measure apo B lipoproteins by measuring apoB
3) LDL-cholesterol and triglycerides are useful but not perfect
4) careful with HDL-cholest
improving our lipids including apoB: diet. more detail on lipids in your blood work
Connect with me:
Facebook: https://www.facebook.com/DrGilCarvalho/
Twitter: https://twitter.com/NutritionMadeS3
Animations: Even Topland @toplandmedia
References:
https://academic.oup.com/eurheartj/article/38/32/2459/3745109
https://jamanetwork.com/journals/jama/article-abstract/2768850
https://jamanetwork.com/journals/jamacardiology/article-abstract/2753612
HDL-cholesterol:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103514/
https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.119.044687
Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.
#NutritionMadeSimple #GilCarvalho
- published: 22 Mar 2021
- views: 45864
9:13
Lipids Series-HDL Can It Be Too High? Is Treatment Available?
Mayo Clinic Division of Preventive Cardiology will be preparing a series of recordings focusing on Cardiovascular Disease states. This is the Lipids Series and...
Mayo Clinic Division of Preventive Cardiology will be preparing a series of recordings focusing on Cardiovascular Disease states. This is the Lipids Series and this particular one focuses on HDL and Treatments
https://wn.com/Lipids_Series_Hdl_Can_It_Be_Too_High_Is_Treatment_Available
Mayo Clinic Division of Preventive Cardiology will be preparing a series of recordings focusing on Cardiovascular Disease states. This is the Lipids Series and this particular one focuses on HDL and Treatments
- published: 04 Jan 2021
- views: 10101
4:56
प्राकृतिक रूपमा एचडीएल ( HDL ) कसरी बढाउने? | Raise your HDL in few steps
You can raise your HDL cholesterol (good cholesterol) with these 5 easy steps. These steps are reliable, easy and the results are permanent as long as you keep ...
You can raise your HDL cholesterol (good cholesterol) with these 5 easy steps. These steps are reliable, easy and the results are permanent as long as you keep doing the steps. A high HDL is very healthy and prevents heart attack and stroke in people just like you.
Don't worry about lowering your LDL, focus all your effort on raising your HDL because it will protect you. There is no prescription drug that will raise your HDL safely and reliably, and very few supplements that actually work.
** QUITTING SMOKING WILL ALSO RAISE YOUR HDL-C! **
Good Berberine: https://amzn.to/3e1ccOj
LIES MY DOCTOR TOLD ME: https://amzn.to/2MtuDjo
REAL SALT you Need: http://bit.ly/RealSalts
-- Research --
Low-Carb Diet
https://pubmed.ncbi.nlm.nih.gov/26224...
https://pubmed.ncbi.nlm.nih.gov/24075...
https://pubmed.ncbi.nlm.nih.gov/26178...
Sleep 7-9 Hours Nightly
https://pubmed.ncbi.nlm.nih.gov/29084...
Proper Fats (Sat & Mono-Unsat)
https://pubmed.ncbi.nlm.nih.gov/19437...
https://pubmed.ncbi.nlm.nih.gov/23510...
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://pubmed.ncbi.nlm.nih.gov/28671...
Vigorous Exercise
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://pubmed.ncbi.nlm.nih.gov/26038...
https://www.ncbi.nlm.nih.gov/pmc/arti...
Stop Smoking
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://accp1.onlinelibrary.wiley.com...
Berberine
https://pubmed.ncbi.nlm.nih.gov/23512...
Disclaimer
Any information on diseases and treatments available at this channel is intended for general guidance only and must never be considered a substitute for the advice provided by a doctor or other qualified healthcare professional.
Always seek the advice of your physician or other qualified health care professional with questions you may have regarding your medical condition.
Although all measures are taken to ensure that the contents of the YouTube channel is accurate and up-to-date, all information contained on it is provided ‘as is’.
We make no warranties or representations of any kind concerning the accuracy or suitability of the information contained on this channel.
Dr. Kurt may at any time and at its sole discretion change or replace the information available on this channel.
To the extent permitted by mandatory law, Dr.kurt ( Diljan Mansoor ) shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.
Contact Details
Maitidevi chowk, 30
01-5907478
9847649625
9823247895
https://wn.com/प्राकृतिक_रूपमा_एचडीएल_(_Hdl_)_कसरी_बढाउने_|_Raise_Your_Hdl_In_Few_Steps
You can raise your HDL cholesterol (good cholesterol) with these 5 easy steps. These steps are reliable, easy and the results are permanent as long as you keep doing the steps. A high HDL is very healthy and prevents heart attack and stroke in people just like you.
Don't worry about lowering your LDL, focus all your effort on raising your HDL because it will protect you. There is no prescription drug that will raise your HDL safely and reliably, and very few supplements that actually work.
** QUITTING SMOKING WILL ALSO RAISE YOUR HDL-C! **
Good Berberine: https://amzn.to/3e1ccOj
LIES MY DOCTOR TOLD ME: https://amzn.to/2MtuDjo
REAL SALT you Need: http://bit.ly/RealSalts
-- Research --
Low-Carb Diet
https://pubmed.ncbi.nlm.nih.gov/26224...
https://pubmed.ncbi.nlm.nih.gov/24075...
https://pubmed.ncbi.nlm.nih.gov/26178...
Sleep 7-9 Hours Nightly
https://pubmed.ncbi.nlm.nih.gov/29084...
Proper Fats (Sat & Mono-Unsat)
https://pubmed.ncbi.nlm.nih.gov/19437...
https://pubmed.ncbi.nlm.nih.gov/23510...
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://pubmed.ncbi.nlm.nih.gov/28671...
Vigorous Exercise
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://pubmed.ncbi.nlm.nih.gov/26038...
https://www.ncbi.nlm.nih.gov/pmc/arti...
Stop Smoking
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://accp1.onlinelibrary.wiley.com...
Berberine
https://pubmed.ncbi.nlm.nih.gov/23512...
Disclaimer
Any information on diseases and treatments available at this channel is intended for general guidance only and must never be considered a substitute for the advice provided by a doctor or other qualified healthcare professional.
Always seek the advice of your physician or other qualified health care professional with questions you may have regarding your medical condition.
Although all measures are taken to ensure that the contents of the YouTube channel is accurate and up-to-date, all information contained on it is provided ‘as is’.
We make no warranties or representations of any kind concerning the accuracy or suitability of the information contained on this channel.
Dr. Kurt may at any time and at its sole discretion change or replace the information available on this channel.
To the extent permitted by mandatory law, Dr.kurt ( Diljan Mansoor ) shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.
Contact Details
Maitidevi chowk, 30
01-5907478
9847649625
9823247895
- published: 06 Mar 2024
- views: 429
1:54:10
240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.
Watch the full episode and view show notes here: http://bit.ly/3XZt1gC
Become a member to receive exclusive content: https://peterattiamd.com/subscribe/
Sign up...
Watch the full episode and view show notes here: http://bit.ly/3XZt1gC
Become a member to receive exclusive content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Dan Rader is a Professor at the Perelman School of Medicine at the University of Pennsylvania, where he conducts translational research on lipoprotein metabolism and atherosclerosis with a particular focus on the function of high-density lipoproteins (HDLs). In this episode, Dan goes in-depth on HDL biology, including the genesis of HDL, its metabolism, function, and how this relates to atherosclerotic cardiovascular disease (ASCVD). He explains why having high HDL-C levels does not directly translate to a low risk of cardiovascular disease and reveals research pointing to a better way to measure the functionality of HDL and predict disease risk. He also goes into detail on the role of HDL in reverse cholesterol transport and the benefits this has for reducing ASCVD. Additionally, Dan discusses the latest thinking around the association between HDL cholesterol and neurodegenerative diseases and ends the conversation with a discussion of how the latest research on HDL provides a promising outlook for ongoing trials and future therapeutic interventions.
We discuss:
-The lipidology of apoB and apoA [4:00];
-A primer on the high-density lipoprotein (HDL): genesis, structure, and more [9:30];
-How the lipoprotein system differs in humans compared to other mammals [20:00];
-Clarifying the terminology around HDL and apoA [25:30];
HDL metabolism [31:45];
-CETP inhibitors for raising HDL-C: does it reduce CVD risk? [34:45];
-Why it’s so important to have hard outcome trials in the field of cardiovascular medicine [42:30];
-SR-B1: an HDL receptor important for cholesterol efflux [48:00];
-The association between HDL levels and atherosclerosis: are they causally linked? [53:15];
-How insulin resistance is impacting HDL, and how HDL-C provides insights into triglyceride metabolism [58:00];
-Disappointing results from the studies of niacin—a drug that raises HDL-C and lowers apoB [1:08:15];
-HDL lipidation, dilapidation, and reverse cholesterol transport [1:12:00];
-Measuring the cholesterol efflux capacity of HDL: a better predictor of ASCVD risk than HDL-C? [1:22:00];
-A promising new intervention that may promote cholesterol efflux and reverse cholesterol transport [1:32:45];
-The association between HDL cholesterol and neurodegenerative diseases [1:34:00];
-Challenges ahead, a promising outlook, and the next frontier in lipidology [1:44:45]; and
-More
--------
About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
Learn more: https://peterattiamd.com
Connect with Peter on:
Facebook: http://bit.ly/PeterAttiaMDFB
Twitter: http://bit.ly/PeterAttiaMDTW
Instagram: http://bit.ly/PeterAttiaMDIG
Subscribe to The Drive:
Apple Podcast: http://bit.ly/TheDriveApplePodcasts
Overcast: http://bit.ly/TheDriveOvercast
Spotify: http://bit.ly/TheDriveSpotify
Google Podcasts: http://bit.ly/TheDriveGoogle
Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.
https://wn.com/240_‒_The_Confusion_Around_Hdl_And_Its_Link_To_Cardiovascular_Disease_|_Dan_Rader,_M.D.
Watch the full episode and view show notes here: http://bit.ly/3XZt1gC
Become a member to receive exclusive content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Dan Rader is a Professor at the Perelman School of Medicine at the University of Pennsylvania, where he conducts translational research on lipoprotein metabolism and atherosclerosis with a particular focus on the function of high-density lipoproteins (HDLs). In this episode, Dan goes in-depth on HDL biology, including the genesis of HDL, its metabolism, function, and how this relates to atherosclerotic cardiovascular disease (ASCVD). He explains why having high HDL-C levels does not directly translate to a low risk of cardiovascular disease and reveals research pointing to a better way to measure the functionality of HDL and predict disease risk. He also goes into detail on the role of HDL in reverse cholesterol transport and the benefits this has for reducing ASCVD. Additionally, Dan discusses the latest thinking around the association between HDL cholesterol and neurodegenerative diseases and ends the conversation with a discussion of how the latest research on HDL provides a promising outlook for ongoing trials and future therapeutic interventions.
We discuss:
-The lipidology of apoB and apoA [4:00];
-A primer on the high-density lipoprotein (HDL): genesis, structure, and more [9:30];
-How the lipoprotein system differs in humans compared to other mammals [20:00];
-Clarifying the terminology around HDL and apoA [25:30];
HDL metabolism [31:45];
-CETP inhibitors for raising HDL-C: does it reduce CVD risk? [34:45];
-Why it’s so important to have hard outcome trials in the field of cardiovascular medicine [42:30];
-SR-B1: an HDL receptor important for cholesterol efflux [48:00];
-The association between HDL levels and atherosclerosis: are they causally linked? [53:15];
-How insulin resistance is impacting HDL, and how HDL-C provides insights into triglyceride metabolism [58:00];
-Disappointing results from the studies of niacin—a drug that raises HDL-C and lowers apoB [1:08:15];
-HDL lipidation, dilapidation, and reverse cholesterol transport [1:12:00];
-Measuring the cholesterol efflux capacity of HDL: a better predictor of ASCVD risk than HDL-C? [1:22:00];
-A promising new intervention that may promote cholesterol efflux and reverse cholesterol transport [1:32:45];
-The association between HDL cholesterol and neurodegenerative diseases [1:34:00];
-Challenges ahead, a promising outlook, and the next frontier in lipidology [1:44:45]; and
-More
--------
About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
Learn more: https://peterattiamd.com
Connect with Peter on:
Facebook: http://bit.ly/PeterAttiaMDFB
Twitter: http://bit.ly/PeterAttiaMDTW
Instagram: http://bit.ly/PeterAttiaMDIG
Subscribe to The Drive:
Apple Podcast: http://bit.ly/TheDriveApplePodcasts
Overcast: http://bit.ly/TheDriveOvercast
Spotify: http://bit.ly/TheDriveSpotify
Google Podcasts: http://bit.ly/TheDriveGoogle
Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.
- published: 30 Jan 2023
- views: 83857